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The pathogenesis of DN is complex, including the disturbance of glycometabolism, abnormal hemodynamics, inflammation and oxidative stress

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The medication may even cause a darkening of the skin in some cases

As CTL1, PNS1, and CherI did not show any activity for either choline or ethanolamine in standard ND96 buffer with 96 mM NaCl, further sodium dependency assays were also not done